Female Participation in the Mwxican Revolution as Narrated by Elena Essay

Female Participation in the Mwxican Revolution as Narrated by Elena Ponitowska and Anna Macias - Essay Example This paper is aimed at providing a brief yet comprehensive overview of the female participation in the Mexican revolution. To provide authentic details acclaimed works by reputed Mexican journalists Elena Poniatowska and Anna Macias will be the focus of this paper. Poniatowska and Macias have resurrected the astonishing stories of various female participants to provide a clear picture of how Mexican Revolution came as an awakening for women and opened the door for their active involvement in political affairs. Poniatowska celebrates the soldaderas' courage and fortitude in â€Å"Las Soldaderas: Women of the Mexican Revolution† and declares, "Without the soldaderas, there is no Mexican Revolution--they kept it alive and fertile, like the earth."1 (Poniatowska, 2006. p. 16) Mexican women who were vulnerable to rape, abductions and mistreatment willingly chose to fight for their land. They were ready to care for the wounded despite the fact that all those people have been deprivi ng them their own civil and political rights for centuries. Large scale warfare began in 1910 and lasted until 1917 during which women were actively engaged in every aspect of the Revolution, contributing intellectual leadership as well as supporting soldiers during the fierce war. Soldaderas were women who traveled with and supported the Revolutionary armies of generals like Villa, Carranza, and Zapata. 2 (King, p. 1) Soldaderas as a term encompasses various aspects in this context. Soldaderas performed most laboring tasks like finding and preparing food for the male soldiers, taking care of the gunpowder so that it does not get wet, collecting firewood and providing medical attention along with the main task of fighting on the front lines of combat. Elena describes that these women mostly belonged to the middle or lower classes. She also narrated the stories of warriors like Rosa Bobadilla who fought in more than 168 combats and became a colonel in the Zapatista army, Carmen Ameli a who Elena writes â€Å"wouldn’t stop caressing the pistol she carried on her right thigh. She’d shoot with her right hand and hold her cigar with her left† 3 (Poniatowska, 2006. p. 19) and Petra Ruiz who was nicknamed as El Echa Balas (the shooter) due to her unparalleled shooting skills. Elena has used the pictures of La Soldaderas by the acclaimed photographer Agustin Victor Casasola on the cover and inside the book to authenticate her narration. Casasola has not only provided pictorial identities of the soldaderas and their images of fighting during the war but also garnered the much required acclaim and dignity to these underrated participants. Countless images of fully armed Mexican women ready to fight were captured by Casasola during the revolution to establish the fact that women did play a prominent role. The pictures also exhibit the difficulties women faced during the revolution at an individual basis. Anna Macias has described the great role played by women and the sacrifices they made during the Revolution with reference to the unfavorable social conditions for females in the era of President Porfirio Diaz. Macias narrated stories of the soldier’s woman. She used the term â€Å"soldier's woman† because of the fact that a female fighter existed in the army via a relationship with a soldier.4 (Macias, 1982. p. 40) It was for this soldier that a soldadera labored. When that soldier died, she would

Understanding of culture and cultural differences as fundamental for Essay

Understanding of culture and cultural differences as fundamental for international marketing - Essay Example The researcher states that culture and cultural differences has not only impacted on the effectiveness of firms with respect to international competitiveness, but has also progressively generated negative effects regarding efficient usage of international marketing resources. Success of international firms is basically dependent on their international marketing strategies that incorporate cross-cultural intelligence aspects. Moreover, international marketing professionals continuously seek to understand global cultures and cultural differences that exist in the international specific markets ventured. Understanding cultural variations that exists among customers and target markets is important for developing an international marketing strategy that is universal and covers all customer needs. Application and outcome of professional marketing largely depends on the extent to which cultural differences are evident among customers. Firm’s competitiveness in the international marke t recognizes cross-cultural factors as determining factors with which comprehensive information is gathered from the various markets to enable formulation of best marketing strategies. Generally, cross-cultural analysis in the international market is similar to domestic market analysis, although international analysis places much emphasis on cultural aspects due to cross border cultural variations. However, domestic markets have also continued to diversify their cultures although as much as the international markets. ... However, domestic markets have also continued to diversify their cultures although as much as the international markets. Political, cultural, and social barriers and variation in the international markets have remained significant challenges to multinational companies that fail to recognize variations, and thus need for different business strategies. Nevertheless, international marketing strategies are more complex and sophisticated with respect to cross border variations as compared to domestic marketing strategies (Rugimbana & Nwankwo, 2003, p.331). International marketing recognizes a variety of cultural aspects that define one country’s culture from the other. Culture is defined and differentiated by technologies with regards to timing, moving, storing, analyzing, and producing information, as well as motives, accuracy, types, timeliness of data collection, language barriers, ethical standards, and attitudes of individuals collecting information. Different clients from dif ferent cultures seek to satisfy similar needs in different ways, which constitute cultures and common practice. Marketing professionals need to devise marketing strategies and products that are not biased to a particular culture, and are able to cover all cultural needs in question. Through research and information analysis, marketing professionals are able to understand the different needs of their customers with regards to their cultural variations. Cross-cultural analysis is carried out by relevant marketing professionals on the target markets of the firms they work for. International marketers seek to analyze particular cultures and the differences pertaining to their marketing strategies using relevant models of study and analysis. Here, cross-cultural research models used by

Fair Value accounting Essay Example for Free

Fair Value accounting Essay The squabble on the issue of what accounting measurements will be used as the standard for financial instruments had caused the on-going debate with various proponents of accounting standard; even today, proponents of every side argues on the basis of their advantages over the others. Among these contending parties are the proponents of the fair value accounting and those who favored accounting standard based on the historical costs. Hitz (2007, p. 324) pointed out the increasing importance of fair value as an accounting measurement attributes. Hitz stated that today, the â€Å"cost and transaction-based reporting model is in decline and a new market value and event-based model is on the rise† (Hitz, p. 324). Citing the significance of fair value accounting, Hitz mentioned that starting out as a specific remedy for the iniquities of the reporting model for certain financial instruments â€Å"fair value has manifested it self as a dominant measurement paradigm for financial instruments and, more recently, has increasingly been implemented for measurements of non-financial items† (Hitz, 324) such as investment property. On the other hand, while Hitz adhere to the tenets of fair value accounting, he recognized the views of the opponents of fair value accounting particularly the criticism regarding the questionable reliability of fair value measures notably for model-based estimates relying on management’s expectation and projections. However, Hitz asserts that results on empirical research regarding value measurement â€Å"support the incremental value relevance of fair value disclosure for securities (Petroni and Wahlen, 1995; Barth et al., 1996 as cited by Hitz). The Australian accounting standards Board (AASB) though recognizes other accounting standards it recognizes fair value accounting as the main financial instruments which applies in various financial processes and transaction within AASB. The AASB defines Fair value as â€Å"the amount for which an asset could be exchanged or a liability settled, between knowledgeable, willing parties in an arms length transaction† (p. 21) Fair value has been the standards in evaluating and managing the performances of a group financial assets or financial liabilities. In the ASSB 7, paragraph 9 to 11 and B 4 the ASSB require the entity to provide disclosures about financial assets and financial liabilities it has designated at fair value through profit or loss including how it satisfied these conditions (ASSB, p. 17). This clearly indicate that fair value accounting as a financial standard instrument have been effectively use and provide significant contribution to the financial situation. This is clearly reflected in the following statement from the ASSB as follows: â€Å"investment in equity instrument that do not have a quoted market price in an active market, and whose fair value cannot be reliably measured shall not be designated as at fair value through profit or loss† (p. 18). The Fair value of any investment plays an important in determining market condition as the fair value of a particular financial instrument is based on the following factors a. the time value of money, b. the credit risk, c. foreign currency exchange prices, d. commodity prices, e. equity prices, f. volatility, and g. payment risk. Regardless of the accounting standard used, accounting plays an important role in financial reporting. While M. J. Milne’s discussion focus on the importance of accounting in financial management including accounting standards that lead to increases in reported earnings,   citing the arguments of Watt and Zimmerman Milne (2002) puts it â€Å"Managers have greater incentives to choose accounting standards which lower earnings thereby increasing cash flows, firm value, and their welfare, due to tax political, and regulatory considerations than to choose accounting standards which reports higher earnings and, thereby increase their incentive compensation† (p. 372). Obviously, accounting standards contributes to the financial situation not only of the firm that uses such standards but the entire financial realm. In this case, Milne partly hinted as to why trillions of dollars went off the global financial market balance sheets and why asset values experience decline. Milne seem to mean that managers choose accounting standards that reported lower earning yet, it increase the firm’s cash flows, the firm value, and their welfare, due to higher tax and political pressures. In this case the real market value as well as the real earnings were reassigned to somewhere else or as Milne suggest, to cash flows and their value. Given this accounting standard, it is no wonder that management will lobby financial instrument that reduce reported earnings to avoid taxes, regulatory procedures, and all other costs. As Milne stressed, â€Å"ordinarily, managers are predicted to have greater incentives to lobby for accounting standards that lead to increase in reported earnings and thereby management wealth. However, since changes in cash flows and stock prices can also be affected by taxes, regulatory procedures, information costs and political costs, managers also have to consider the effects of reported earnings might have on the likelihood that such costs could be imposed on the firm† (p. 372). The trillions of dollars that were written off the global financial market balance sheets and the massive decline of asset values can therefore be attributed to these factors accompanying this accounting standard, and the commentators were partly right in their opinion regarding this massive decline of asset values. However, this does suggest that that money going to taxes, regulatory procedures, political costs, and information costs are lost money and that regulatory procedure should be viewed as negative for business activities. Regulatory procedures should be viewed in even broader terms that include all forms of social control and influence. Michael Greiffin emphasized that this should also include â€Å"not only the corporations legislative requirement but also other rules and directions, such as professional accounting standards and stock exchange requirements† (p. 2 par. 3). Graffikin pointed out that regulation is considered desirable â€Å"where there windfall profits† – where through some fortuitous event is able to make above â€Å"normal† profits. Regulations should be seen as necessary in the rationalization and coordination of economic activity so as to organize behaviour of industries in an efficient manner (graffikin, p. 3).

Data Security Policy Analysis

Data Security Policy Analysis Dylan Mc Grath   The reason for having a policy: The reason for having the policy is so that the workers at ACME LEARNING Ltd know what to do when they are assessing the personal data of the customers and how they will use the data. A Brief explanation of the companys obligations under the law: There is one main legislation which the company has to obligate by it is called the Data Protection Act 1998 which was also amended in 2003. It was created for when personal details are given to a company they have to keep the details and they cannot be given to anyone outside of the company. Every person who has given their details to the company can request a copy of their information that the company has. The company must send the person their details within 40 days. They can also have their name removed from any marketing list. They could also make a complaint to the data commissioner if the company is not adhering to the Protection Acts rules. A person can claim compensation if they suffer when the company uses their data in a wrong way. Who is effected by how the company uses and stores data? The people that are effected by this are: Teachers and Staff who work for ACME LEARNING Ltd Management Students The Data that is stored about them is: Credit Card/ Bank Details Birth Dates Contact details Name Address Email Gender PPS Numbers Suppliers information Why the data is used by ACME LEARNING Ltd: For advertising and marketing purposes. To have a database of a persons information. For payroll and pension administration To make the names and addresses of people are correct. To stop fraud and money laundering For record keeping What Specific Threats does AMCEs data have? Malware: Malware is software that can harm a computer and can slow down performance. Hacking: Getting into a computer authorized or unauthorized without wanting to cause any damage. Weather Conditons and Fires: data can lost by storms, earthquakes and floods.   Fires can also be started by accident when the server room is too hot. When these weather conditions and fires happen the server rooms can be completely destroyed. Adware: Software that can monitor the users online activities so that the person can be targeted by advertisements. Disgruntled employees Spyware Accidents Theft Human Error Copying data onto storage devices. Trojans Roles and Responsibilities: Data Controller ACME LEARNING Ltd must appoint a Data Controller who is there to deal with the data which is about their customers on a computer and also in a filing cabinet. The Data Controller must: 1: Obtain and process the information fairly. 2: Keep it only for what is it was needed for. 3: Use it for and it should only be given out for a specified purpose. 4: It must be kept safe and secured. 5: The information must be kept up to date and correct. 6: Make sure the data is adequate, relevant and not excessive. 7: It must not be kept for any longer than it is needed for. 8: Give a copy of his/her personal data on their request. Every Employee that works for ACME LEARNING LTD has to be given training on how to use and handle the data. Rules for:1. Data storage: Data on hard drives cannot be deleted. The data has to be stored on the network drive where the I.T department can back it up when they need to. Data that is on paper has to be kept in a safe place. Data has to be protected by strong passwords. All data has to be stored on the server and data has to in a safe location. The Data Controller and only the people who need to access the data are allowed to look at it. Servers and computers that have data have to be protected by a firewall and security software. Data on CDs or DVDs has to be locked away. The servers have to have different sites in case one site goes offline. Data should not be saved on laptops or other mobile devices. There will be two different databases for both staff and students information. The data cannot be stored locally have it in a place where it can be backed up every night. Data has to be backed up every night. The usb ports on all the machines have to be disabled. Every computer in the building has to be rebooted every night at a certain time. There are two databases one for staff and the other for students information. Users have to logout of their computer to make the data stays safe. The person that looks at the data should be able to see the quantity of the data and the duplication. 2. Data use When looking at data on a computer all employees must have their computer locked when they are away from their desk. Employees cannot make a duplicate of any data on a file. When data is being transferred electronically it has to be encrypted. 3. Data accuracy: ACME Learning LTD must keep the data up to date and accurate. Data that is inaccurate should be updated to the correct data by someone that is allowed to edit the data. There are staff that are allowed to edit the data and other staff who are only allowed to read the data. 4. Data access requests: The Data Protection Act lets a person find out if ACME LEARNING Ltd has any information that relates to them. The person has to either fill out a form or write a letter to the company asking for their information. The person has to include identification so that the company knows that they are giving the data to the right person. The person is entitled to: A copy of the data. A description of the use for which it is held. A description of those to whom the data may be shown to. The source of the data. The person may have to pay a fee to access their information which cannot exceed â‚ ¬6.35. The person has to be contacted within 40 days with their data or be told that the company does not have any data about them. 5. Data Disposal: ACME LEARENING LTD will keep the data it has for employees for seven years only if it is financial. ACME LEARENING will keep the students data for three years. If a student has ticked a box to say that they want ACME LEARENING LTD to keep their exam results then ACME LEARENING LTD has to keep the students exam results for a certain number of years. If data is on paper it has to be thrown into a waste bin. It must also be recycled. The paper can also be shredded so that the data on the paper will be destroyed. An incinerator can be used to burn the paper to destroy it so no one can recover any of the data on the sheets. Hard Drive Disposal: At the time the hard drives need replacing an employee must carry out the procedures that need to be done. The procedures are to overwrite a hard drive, get the hard drive destroyed by paying a company that deals with destroying hard drives the right way so that the data is safe from being seen by a person that wants to use it for gaining money. The hard drive can also be degaussed. This removes all the data from the hard drive. Degaussing destroys the magnetic fields on the hard drive. It completely makes the hard drive in tiny pieces so that it cannot ever be used again. Overwriting the data using a program puts binary numbers onto the hard drive. It should be done at least three times to be successful. Tape Media Disposal: The data on the tapes can be overwritten. They can also be incinerated this method will completely destroy the tape. This method will pollute the air.   The data on the tapes can be degaussed. The company can get someone to come in and do it to witness that the tape has been degaussed properly.

Urinary Excretion and Paracetamol

Urinary Excretion and Paracetamol Investigateurinary excretion of paracetamol in man. Paracetamol, known as acetaminophen in the USA, is one of the most commonly used analgesic and antipyretic drugs available over-the-counter. Its common name derives from the full chemical name: para-acetyl-amino-phenol, with the chemical formula C8H9NO2 and amolecular weight of 151.17. Paracetamol does not have anysignificant anti-inflammatory action and therefore cannot be accuratelydescribed as a non-steroidal anti-inflammatory drug (NSAID), as was oncethought. Its mechanism of action is still poorly understood but some studieshave suggested that it inhibits a variant of the cyclo-oxygenase enzyme COX-1, which has been designated COX-3 (Swierkosz et al. 2002). Paracetamol actsmainly in the central nervous system and endothelial cells, rather than inplatelets and immune cells. Boutaud and colleagues (2002) hypothesised thatthis may be explained by the high levels of peroxides found in the latter cell types, which inhibit the action of paracetamol. There has been some debate on thesubject, with other researchers proposing an inhibitory action against COX-2(Graham Scott 2005). Further research is required to fully elucidate the mechanism of action at the molecular level. Metabolism and excretion Following oral administration and absorption from the gastrointestinal tract, paracetamol enters the blood and is distributed throughout the body. It is metabolised by enzymes in the hepatocytes of the liver and the majority is converted to inactive metabolites by conjugation with sulphate or glucuronide. This is then filtered out of theblood by the kidneys and into the urine, via active renal tubular secretion. Asmall portion of paracetamol remains unaltered and passes into the urine viaglomerular filtration and passive absorption (Morris Levy 1984). Thereis also a small proportion of the paracetamol that is metabolised by the thecytochrome P450 system, which results in the formation of cysteine or glutathioneconjugates and mercapturic acid conjugates (figure 2). These products ofoxidative metabolism are also excreted renally (Andrews et al. 1976). Paracetamol has a low therapeuticindex, so the therapeutic dose is very close to the toxic dose. Toxicity canoccur following a single large dose (>10g) or with chronic lower doses(4-5g/d) and is usually seen as hepatotoxicity, which can result in deathwithin several days (Wikipedia). Toxicity occurs when the enzymesresponsible for catalysing sulphate and glucuronide conjugation becomesaturated, forcing metabolism to be increasingly dependent upon the cytochromeP450 system. This results in formation of a toxic metabolite,N-acetyl-p-benzo-quinone imine (NAPQI), which is normally mopped up by bindingto the sulphydryl group of glutathione to form inactive conjugates andmercapturic acid. Toxicity occurs when the glutathione supply becomes exhaustedand NAPQI binds indiscriminately to molecules within the cell, such asmembranes, to cause cell damage and death, seen as acute hepatic necrosis. 1)Major pathway for normal metabolism 2)Minor pathway via cytochrome P450 system produces toxic metabolite (NAPQI),shown in red. Normally this is detoxified by binding to glutathione. 3) Toxicity occurs when pathways 1 and 2 are overloadedand NAPQI binds to molecules of the cell, causing damage. Modifiedfrom Rang et al. 1995. Aim of experiment The aim of this experiment is toinvestigate the renal excretion of paracetamol, by measuring the levels ofparacetamol metabolites in human urine over 6 hours following an oral dose of500mg. The total excretion will be assessed using the spectrophotometricmethod. From this data the elimination rate constant (KE) and thehalf-life (T1/2) will be calculated. Qualitative analysis of thevarious metabolites will be conducted using appropriate chemical identificationtechniques. METHOD A standard stock solution ofparacetamol was prepared at 1mg/cm3 and dilutions were made to givea range of known concentrations. 1 cm3 of the paracetamol solutionwas added to 1 cm3 blank urine and 4 cm3 4M HCl, andmixed thoroughly. A blank duplicate was also prepared, using water instead ofurine. After an hour in a boiling water bath the tubes were cooled and wateradded, up to 10 cm3. 1 cm3 of this hydrolysed urinesolution was added to 10 cm3  of colour forming solution, mixed and allowed to stand for40 minutes. The absorbance of each solution was measured, using thespectrophotometer, zeroing the instrument using the drug free urine sample inbetween solutions. This produced the readings for the calibration curve. Thecollected timed urine samples were then processed in the same way, adding 1 cm3water instead of paracetamol solution. RESULTS AND DISCUSSION Known concentrations of paracetamolunderwent spectrophotometry to measure the absorbance at 620nm. These resultswere used to produce a calibration curve (figure 3). The timed urine sampleswere then analysed following the same protocol and the absorbance at 620nm wasused, in conjunction with the calibration curve to ascertain the concentrationof paracetamol in the urine. Unfortunately, half of the samples producedabsorbances outside the range of the calibration curve. Because this curve isnon-linear, extrapolation and dilution cannot be used to accurately deduce theconcentration of paracetamol in the urine. For the purposes of this report theconcentration for these samples has been declared as greater than 800ug/cm3.This is not very satisfactory and further experiments must be done to extendthe range of the calibration curve to the maximum absorbancy of the timedsamples. The values of KE and T1/2 have been calculatedto demonstrate the procedure, but are inaccurate and will need revisi ng onceaccurate concentrations have been established form the calibration curve. Table 1: Timed urine sample Mean absorbance 620nm Conc. ug/cm3 Vol. Urine (ml) Total drug (ug of paracetamol) Excretion rate mg/h 0 0 0 0 0 0 1 hour 0.256 192 245 47040 47 2 hours 1.918 >800 50 40000 40 3 hours 1.769 >800 38 30400 30.4 4 hours 1.028 >800 55 44000 44 5 hours 0.349 246 135 33210 33.2 6 hours 0.255 192 160 30720 30.7 Table 1 contains the absorbanceresults of the timed urine samples and the deduced concentration of paracetamolin the urine, as well as the hourly excretion rate. The total amount ofparacetamol excreted over the 6 hour period was 225.3mg, which is 45% of theorally administered dose. Due to problems discussed above, this is anunderestimate of the true percentage of dose excreted renally, which has beenfound to be 55-70% by other studies (Steventon et al. 1996). When log of the excretion rate(equivalent to total drug excreted per hour) is plotted against time, a linearplot should be achieved, from which KE can be estimated. The slope of this straight lineequates to : KE /2.303, which gives a value for KE of0.094. Using the formula: T1/2 =0.692/ KE , the valueof T1/2 = 7.36 hours. This states that it takes the body7.36 hours to excrete half of the drug administered. This is longer than the1-4 hours usually quoted for paracetamol (Rang et al. 1995), and is notsurprising given the underestimation of the paracetamol urine concentration.With proper calibration, this would be expected to decrease to nearer thepreviously found results. There were no results for thequalitative studies for metabolite composition, but it would be expected thatsulphate and glucuronide conjugates would constitute the majority of the sample,with a smaller quantity of unchanged paracetamol, cysteine/glutathione andmercapturic acid metabolites. These results only represent oneindividual on one day and replications of this experiment are crucial.Nutritional status, recent alcohol consumption, ethnic background, concurrentdrug usage and illness must all be taken into account as factors that mayaffect paracetamol metabolism and excretion (Riordan Williams 2002, Patel Tang 1992). Further analysis of paracetamolexcretion .  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Hepatotoxicity and drug interactions Table 2 shows how concurrent use of phenobarbital, ananti-epileptic drug, can increase the severity of liver damage caused byparacetamol administration and its subsequent metabolism. Table 2: Effect of Phenobarbital onparacetamol induced hepatotoxicity TreatmentDose of Paracetamol (mg/kg) Severity of liver necrosis None 375 1-2+ Phenobarbital 375 2-4+_________ This occurs due to metabolism ofphenobarbital by enzymes of the P450 cytochrome system, which results inupregulation of their production. As explained in the introduction (see fig.2), P450 enzymes also metabolise paracetamol, to form the toxic metaboliteNAPQI. This is normally a minor pathway but as the amount of P450 enzymesavailable increases, the activity of this pathway also increases. This resultsin a larger than normal amount of NAPQI, which is mopped up and inactivated byglutathione. Glutathione supplies will eventually run out, which occurs soonerif the person is malnourished. When this happens the toxic metabolite binds tocell components, causing necrosis. To prevent this occurring, such as in casesof overdose, N-acetylcysteine can be given (Routledge et al. 1998), which isrequired for glutathione synthesis and helps to boost it. This allows agreater amount of the toxic metabolite to be mopped up and reduces cell damage. .  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Ã‚  Paracetamol metabolism following hepatotoxicity Table 3: Plasmaparacetamol concentrations(ug/cm3) Patients Plasma paracetamol 4 hrs after 12hrsafter Half life (h) ingestion ingestion _______________________________________________________________ noliver damage (18) 2.9 +/= 0.3 163 +/=20 29.5 +/=6 liverdamage (23) 7.2+/= 0.7 296 +/= 26 124 +/=22___ Table 3 shows that, in a study, theability of patients with liver damage to eliminate paracetamol from the bloodis much decreased, compared to healthy people. This is seen by the prolongedhalf-life and the high levels of paracetamol in the plasma. The plasma leveldoes come down by 12 hrs, which indicates that there is enough functional liverreserve to metabolise some of the drug, but the level is still very high. Toascertain whether it is just conjugation that is affected, or whether all thepathways are affected equally it would be necessary to quantify the levels ofdifferent metabolites in the blood and urine. As conjugation is responsiblefor the majority of metabolism, damage to all systems will still show up asaffecting conjugation the most. In theory reduced clearance of asubstance is useful for monitoring the severity of liver damage, but in thecase of paracetamol it would be unwise as it could potentiate the hepatotoxiceffects and worsen the liver condition. It is also unnecessary as there arealready a number of reliable blood tests for liver function and damage. REFERENCES Andrews, R. S., Bond, C. C., Burnett, J., Saunders, A. Watson, K. 1976 Isolation and identification of paracetamol metabolites. J Int Med Res 4,34-9. Boutaud, O., Aronoff, D. M., Richardson, J. H., Marnett, L. J. Oates, J. A. 2002 Determinants of the cellular specificity of acetaminophen as an inhibitor of prostaglandin H(2) synthases. Proc Natl Acad Sci U S A 99,7130-5. Graham, G. G. Scott, K. F. 2005 Mechanism of action of paracetamol. Am J Ther 12, 46-55. Morris, M. E. Levy, G. 1984 Renal clearance and serum protein binding of acetaminophen and its major conjugates in humans. J Pharm Sci 73, 1038-41. Patel, M., Tang, B. K. Kalow, W. 1992 Variability of acetaminophen metabolism in Caucasians and Orientals. Pharmacogenetics 2, 38-45. Rang, H. P., Dale, M.M., Ritter, J.M. 1995 Pharmacology: Churchill Livingstone. Riordan, S. M. Williams, R. 2002 Alcohol exposure and paracetamol-induced hepatotoxicity. Addict Biol 7, 191-206. Routledge, P., Vale, J. A., Bateman, D. N., Johnston, G. D., Jones, A., Judd, A., Thomas, S., Volans, G., Prescott, L. F. Proudfoot, A. 1998 Paracetamol (acetaminophen) poisoning. No need to change current guidelines to accident departments. Bmj 317, 1609-10. Steventon, G. B., Mitchell, S. C. Waring, R. H. 1996 Human metabolism of paracetamol (acetaminophen) at different dose levels. Drug Metabol Drug Interact 13, 111-7. Swierkosz, T. A., Jordan, L., McBride, M., McGough, K., Devlin, J. Botting, R. M. 2002 Actions of paracetamol on cyclooxygenases in tissue and cell homogenates of mouse and rabbit. Med Sci Monit 8, BR496-503. http://en.wikipedia.org/wiki/Paracetamol.

Hiding From The Truth :: essays research papers

Hiding From The Truth! In the reading, "The Story of an Hour," many things weren’t as they seemed. This is called symbolism. Where one write something and it symbolizes another thing. For example, someone’s blood gets warmer. That wouldn’t symbolize them getting hot, it symbolizes them having a warm and happy feeling about something. This shows that things aren’t thought of as they are supposed to be. Symbolism also leads to hidden truths. Things that also don’t mean what they seem. Just as symbolism, hidden truths need to be thought out, and thoroughly processed in one’s head. In the reading, "The Story of an Hour," many things aren’t as they seem, leading to hidden truths, symbolism, and an unusual ending. There were many things that could be considered to be hidden truths in the reading. There were just a few that stuck out with ease. One of the hidden truths would be when the wife Louise Mallard is thinking about the news she was just told, she is sitting in a "comfortable roomy chair," comfort and roominess are relaxing and fun. The reason the writer uses comfortable and roomy is to show that the wife, Louise, was happy and relaxed when she heard the news and thought about it. She was pretty much happy with the result. Another easy hidden truth was when Louise was saying, "free, free, free" and "free, body and soul free." These phrases would, in reality, show that she was happy and felt like her own self now. She wasn’t restricted by her husband, he was gone and she was her own woman. She was finally "free" as she would say. And finally, Louise’s pulse beats harder. That is just like the blood warming. Her pulse beatin g hides that she is full of joy. She is happy of what happened, and that she is "free." There are many truths that are hidden in this story, that just leads to making the readers get into the story. Not only were there hidden truths, but a lot of symbolism came up in the reading. The symbolism starts with an open window. That is what Louise was staring at and looking through when she was told about the death of her husband Brently. The open window symbolizes freedom. Louise was now free of her husbands rein. She was unhappy with the marriage and liked finally being free and her own person.

Reviewing Sullivan?s Study of America?s Wine :: essays research papers fc

For many years, wine dictionaries and encyclopedias have unknowingly been misleading consumers on the history of â€Å"America’s wine,† Zinfandel. In Zinfandel, A History of a Grape and Its Wine, Charles Sullivan, an accomplished viticulture researcher, challenges the popular belief that the grape was originally brought to America by a Hungarian immigrant. Sullivan explores the history of wine to bring forth intriguing facts that prove the popular belief to be wrong. With the help of University of California’s (UC’s) Carole Meredith, a new idea is thoroughly explained describing the true ancestry of Zinfandel.   Ã‚  Ã‚  Ã‚  Ã‚  For those not familiar with the wine it is important to note that Zinfandel, according to Sullivan, was the first and most successful American wine. Typically, wines from France and Italy prove to be more superior in taste than the American counterparts. However, with Zinfandel this is not the case. Unlike aged and dry wines, the young, fruity flavor of the Zinfandel makes for a more enjoyable flavor that appeals to a greater number of people’s tastes.   Ã‚  Ã‚  Ã‚  Ã‚  Sullivan does an excellent job keeping the book enjoyable by providing readers with intriguing side notes. For example, here he tries to illustrate the extreme passion that the Californians had for Zinfandel. â€Å"So great was the Napa passion for this grape that one of the tiny railroad stations below St. Helena was renamed â€Å"Zinfandel.† By the 1880s Zinfandel Lane crossed the valley, and the steamer Zinfandel plied the bay waters between San Francisco and the wharves of Napa City.† (Sullivan, 2003) This passage is a perfect example of why this book was enjoyable for me.   Ã‚  Ã‚  Ã‚  Ã‚  However, there are times during the book where Sullivan becomes longwinded when it comes to explaining certain points. Long paragraphs embedded with, at times, insignificant graphics and charts make the book a hard and slow read. Yet, my curiosity and desire to learn helped me overcome the craving to close the book.   Ã‚  Ã‚  Ã‚  Ã‚  The desire I did have to close the book may have been attributed to the amount of â€Å"wine lingo† found within the text. The excessive amount of references to other wine varieties made it extremely tiresome, as I had to repeatedly look up in dictionaries and encyclopedias the characteristics of a certain wine he was describing. I believe that a person more educated in the subject of wine would enjoy this book more than an uneducated person like me. If a reader is not familiar with wine, the book can be quite discouraging at times.